Dr. Andrea Brennan, certified lymphedema specialist, begins the Lymphedema Series with a presentation on the diagnosis and evidence-informed treatment of lymphedema. Dr. Brennan describes the pathophysiology and stages of lymphedema, mechanism of compression bandaging, and options for compression in the lymphedematous limb. Dr. Brennan reviews lymphatomes and the proper sequencing of manual lymphatic drainage. Differential diagnosis of phlebolymphedema, lipedema, and lipo-lymphedema is discussed. The module concludes with case examples comparing pre and post-treatment results.